NIH COMMON FUND HIGH-RISK HIGH-REWARD RESEARCH SYMPOSIUM DECEMBER 15 – 17, 2014 SPEAKER ABSTRACTS Interactomics: Computational Analysis of Novel Drug Opportunities Awardee: Ram Samudrala Award: Pioneer Award

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• Clinical pharmacology
• Bioinformatics
• Clinical research
• Drug discovery
• Proteomics
• Food and Drug Administration
• Pharmaceutical sciences
• Pharmacology
• Medicinal chemistry

Song Description By Ram Samudrala of the University of Washington

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TECHNICAL COMMENT Comment on ‘‘Evidence for Positive Epistasis in HIV-1’’ Kai Wang, John E. Mittler, Ram Samudrala* Bonhoeffer et al. (Reports, 26 November 2004, p[removed]presented evidence for positive epistasis

Source URL: compbio.washington.edu

• Christianity
• Evolution of sexual reproduction
• Antiretroviral drug
• Virus
• Dietrich Bonhoeffer
• Nazi Germany
• Evolutionary biology
• Epistasis
• Biology

Nucleic Acids Research, 2005, Vol. 33, Web Server issue W77–W80 doi:[removed]nar/gki403 PROTINFO: new algorithms for enhanced protein structure predictions Ling-Hong Hung, Shing-Chung Ngan, Tianyun Liu and Ram Samudrala

Source URL: www.ram.org

• Chemistry
• Protein structure
• Biology
• Protein structure prediction
• CASP
• Homology modeling
• EVA
• Threading
• Biomolecular structure
• Bioinformatics
• Protein methods
• Science

Antiviral Therapy 9:703–712 Antivirogram or PhenoSense: a comparison of their reproducibility and an analysis of their correlation Kai Wang, Ram Samudrala and John E Mittler* Department of Microbiology, University of

Source URL: compbio.washington.edu

• Biochemistry
• Titration
• IC50
• Science
• Antiretroviral drug
• Chemistry
• Laboratory techniques
• Assay

Bioorganic & Medicinal Chemistry Letters[removed]–3992 Identifying Inhibitors of the SARS Coronavirus Proteinase Ekachai Jenwitheesuk and Ram Samudrala* Computational Genomics Group, Department of Microbiology,

Source URL: compbio.washington.edu

• Biochemistry
• Enzymes
• Metabolism
• HIV/AIDS
• Protease inhibitor
• AutoDock
• Protease
• SARS coronavirus
• Coronavirus
• Chemistry
• Biology
• Nidovirales

The Bioverse: An object-oriented genomic database and webserver written in Python Jason McDermott and Ram Samudrala Department of Microbiology, University of Washington [removed] [removed]i

Source URL: www.ram.org

• Database management systems
• Proteomics
• Computational phylogenetics
• Biological databases
• Protein–protein interaction prediction
• Genome project
• BLAST
• Structural genomics
• Object database
• Bioinformatics
• Science
• Biology

Chapter 22 The Bioverse API and Web Application Michal Guerquin, Jason McDermott, Zach Frazier, and Ram Samudrala Abstract The Bioverse is a framework for creating, warehousing and presenting biological information based

Source URL: www.ram.org

• Biological databases
• Molecular biology
• Systems biology
• Proteomics
• Interactome
• Functional genomics
• Protein–protein interaction
• DNA
• Protein
• Biology
• Science
• Bioinformatics

Chapter 23 Computational Representation of Biological Systems Zach Frazier, Jason McDermott, Michal Guerquin, and Ram Samudrala Abstract Integration of large and diverse biological data sets is a daunting problem facing

Source URL: www.ram.org

• Data warehousing
• Database theory
• Database management systems
• Data modeling
• Online analytical processing
• Aggregate
• Star schema
• Data warehouse
• Data integration
• Data management
• Data
• Information

Antiviral Therapy 9:[removed]Simple linear model provides highly accurate genotypic predictions of HIV-1 drug resistance Kai Wang, Ekachai Jenwitheesuk, Ram Samudrala and John E Mittler* Department of Microbiology, Unive

Source URL: compbio.washington.edu

• Organic chemistry
• Bristol-Myers Squibb
• Organofluorides
• Purines
• Cyclopropanes
• Antiretroviral drug
• Virco
• Reverse-transcriptase inhibitor
• Abacavir
• Chemistry
• Medicine
• HIV/AIDS